Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specification
نویسندگان
چکیده
منابع مشابه
mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila.
Establishment of the anteroposterior and dorsoventral axes in the Drosophila egg chamber requires reciprocal signaling between the germ line and soma. Upon activation of the Drosophila EGF receptor in the posterior follicle cells, these cells signal back to the oocyte, resulting in a reorganization of the oocyte cytoplasm and anterodorsal migration of the oocyte nucleus. We demonstrate that the...
متن کاملThe mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila
BACKGROUND Drosophila axis formation requires a series of inductive interactions between the oocyte and the somatic follicle cells. Early in oogenesis, Gurken protein, a member of the transforming growth factor alpha family, is produced by the oocyte to induce the adiacent follicle cells to adopt a posterior cell fate. These cells subsequently send an unidentified signal back to the oocyte to i...
متن کاملDrosophila glypicans regulate the germline stem cell niche
Stem cells are maintained in vivo by short-range signaling systems in specialized microenvironments called niches, but the molecular mechanisms controlling the physical space of the stem cell niche are poorly understood. In this study, we report that heparan sulfate (HS) proteoglycans (HSPGs) are essential regulators of the germline stem cell (GSC) niches in the Drosophila melanogaster gonads. ...
متن کاملMago nashi is essential for spermatogenesis in Marsilea.
Spermatogenesis in Marsilea vestita is a rapid process that is activated by placing dry microspores into water. Nine division cycles produce seven somatic cells and 32 spermatids, where size and position define identity. Spermatids undergo de novo formation of basal bodies in a particle known as a blepharoplast. We are interested in mechanisms responsible for spermatogenous initial formation. M...
متن کاملThe mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila.
In Drosophila, the localization of maternal determinants to the posterior pole of the oocyte is required for abdominal segmentation and germ cell formation. These processes are disrupted by maternal effect mutations in ten genes that constitute the posterior group. Here, the molecular analysis of one posterior group gene, mago nashi, is presented. Restriction fragment length polymorphisms and t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2007
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2007.06.007